Hyperforin Accumulates in the Translucent Glands of Hypericum perforatum

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Hyperforin accumulates in the translucent glands of Hypericum perforatum.

BACKGROUND AND AIMS Hypericum perforatum contains the therapeutically important compounds hypericin and hyperforin. Hypericin is known to accumulate in the dark glands. This investigation aimed to determine the accumulation site of hyperforin. METHODS Dark and translucent glands as well as non-secretory tissue in leaves were manually isolated under the microscope. Hyperforin content was quant...

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Transgenic Hypericum perforatum.

Plant transformation is an important tool with many applications in modern plant biology. Although this technique is primarily used to produce superior crop varieties, it is also being utilized to answer basic questions concerning gene function and regulation in contemporary functional genomics research. In our laboratory, we have established a transformation system for Hypericum perforatum. Th...

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Biosynthesis of the Active Hypericum perforatum Constituents

Extracts from Hypericum perforatum (St. John’s wort; Clusiaceae) are widely used for the treatment of mild to moderate depression. Four classes of constituents – hyperforins, hypericins, flavonoids, and xanthones – appear to contribute to the antidepressant activity. Interestingly, all four classes of secondary metabolites involve polyketide derivatives. Key reactions of their biosyntheses are ...

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Hypericum perforatum: nature's mood stabilizer.

Hypericum perforatum (HP), better known as St. John's Wort, has been used clinically for centuries. Modern usage is still quite diverse and includes kidney and lung ailments, insomnia and depression. Standardised extracts of HP are widely used in the treatment of psychovegetative disorders and especially for mild forms of depression. Several bioactive constituents of this plant may play importa...

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ژورنال

عنوان ژورنال: Annals of Botany

سال: 2007

ISSN: 0305-7364,1095-8290

DOI: 10.1093/aob/mcm057